Jacob D. Aubrey

Chemist and medical-imaging researcher

Chemistry Ph.D. candidate Rensselaer Polytechnic Institute (RPI) (opens in a new tab) Bonitatibus Lab (opens in a new tab)

I work at the interface of contrast-agent chemistry and medical imaging physics. My current research in the Bonitatibus Lab focuses on tantalum oxide nanoparticles and photon-counting CT.

Portrait of Jacob D. Aubrey
NANOPARTICLE CHEMISTRY HIGH-Z CONTRAST PHOTON-COUNTING CT

Research

Co-designing contrast agents and imaging methods

Nanoparticle graphic and NMR spectrum background illustrating chemical synthesis and characterization.

01

Contrast-agent development

I design and characterize high-Z contrast agents, with a particular focus on carboxybetaine zwitterionic–coated tantalum oxide (CZ TaOx) nanoparticles. Using multinuclear NMR and complementary techniques, I investigate how coating architecture, particle size, and surface chemistry influence imaging performance and physicochemical properties relevant to biological compatibility.

Photon-counting CT phantom with a magnified material-specific reconstruction.

02

PCCT protocol optimization

I develop and evaluate photon-counting CT acquisition and reconstruction strategies for quantitative imaging, with a particular focus on protocol development for emerging high-Z contrast agents. I investigate how energy threshold selection, spectral shaping, and reconstruction choices influence material decomposition accuracy, contrast–noise performance, spatial resolution, and metal artifact severity—and how these effects vary by contrast material.

Conceptual illustration of a nanoparticle platform connecting cardiovascular, oncology, and multimodal imaging directions.

03

Translational imaging directions

Looking ahead, I am interested in co-developing contrast agents and imaging methods for key clinical applications such as quantitative cardiovascular and oncology imaging. I am particularly interested in multi-contrast and multimodal imaging, ultra-small inorganic nanoparticles, intraoperative agents, and theranostics.

Selected publications

Research in print

For a complete and current publication record, visit Google Scholar.

View all publications (opens in a new tab)
  1. Physics in Medicine & Biology 2026

    Material-dependent effects of x-ray pre-filtration on material decomposition in photon-counting CT

    Jacob D. Aubrey, Emmett P. Perkinson, Ge Wang, and Peter J. Bonitatibus Jr.

    Read article (opens in a new tab)
  2. Physics in Medicine & Biology 2025

    Metal artifact reduction and contrast agent performance as a function of source spectral shape

    Jacob D. Aubrey, Emmett P. Perkinson, Ge Wang, and Peter J. Bonitatibus Jr.

    Read article (opens in a new tab)
  3. Academia Nano: Science, Materials, Technology 2025

    Insights into nanoparticle surface bonding and coating architecture via multinuclear NMR

    Jacob D. Aubrey, James Gibson, John T. Leman, Benjamin M. Yeh, and Peter J. Bonitatibus Jr.

    Read article (opens in a new tab)

Recognition

Selected awards and fellowships

  • 2026 Slezak Memorial Graduate Fellowship
  • 2026 Professor Ronald A. Bailey Graduate Student Travel Award
  • 2026 Best Oral Presentation, NY Capital Region Society for Applied Spectroscopy Symposium
  • 2024–26 NIGMS Training Program in Biomolecular Science and Engineering Fellow

Curriculum vitae

A complete academic record.

Download a current academic CV, including research experience, publications, presentations, teaching, and selected recognition.

Download CV (PDF; opens in a new tab)

Contact

Let's connect.

For research conversations, collaborations, or speaking inquiries, email is the fastest way to reach me.